相关实验视频
Updated: Jul 6, 2025

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
23.5K
[世界卫生组织对上腺皮层瘤分类第五版的解释]
1Department of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Zhonghua bing li xue za zhi = Chinese journal of pathology
|January 5, 2024
概括
世卫组织第五版分类改进了上腺皮层瘤诊断,更新了结节性疾病的命名法和儿童瘤的新标准. 它强调扩散评估和辅助研究,以更好地分层风险.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 世界卫生组织对上腺皮层瘤的第五版分类引入了重大更新.
- 现在包括非新生病变和精细瘤概念.
- 名称的变化侧重于上腺皮质结节性疾病的分类.
研究的目的:
- 根据世界卫生组织第五版分类,审查上腺皮层病理学的进展.
- 为突出更新的上腺瘤的诊断标准和分类.
- 强调组织学特征,辅助研究和遗传发现的重要性.
主要方法:
- 第五版世卫组织上腺皮层瘤分类的综述.
- 对上皮层结节性疾病的最新命名的分析.
- 包括HISTALDO对生产阿尔多素的病变的分类.
- 对癌瘤的韦斯和林-韦斯-比塞格利亚标准的评估.
- 整合Reticulin算法,赫尔辛基和维也纳系统进行差异诊断.
- 强调线粒细胞计数和Ki-67标记指数用于扩散评估.
主要成果:
- 非新生病变的病变,如上腺休息和囊现在被分类.
- 上皮层结节性疾病被细化为零星,双边微结节性和双边宏结节性类型.
- 通过CYP11B2免疫组织化学来支持阿尔多的产生.
- 在癌瘤中血管侵袭的诊断和预后影响被强调.
- 专门的系统 (Reticulin,赫尔辛基,Wieneke) 引入用于差异诊断.
- 准确评估瘤增殖率对于风险分层至关重要.
结论:
- 世界卫生组织第五版分类提高了对上腺皮层病理的理解和诊断.
- 更新的标准改善了上皮层结节性疾病和癌症的分类.
- 辅助研究和扩散标记对于准确的诊断和风险分层至关重要.
相关概念视频
Adrenal Gland Disorders
1.5K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K
Anatomy of the Adrenal Glands
2.3K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.3K
Hormones of the Adrenal Glands
2.5K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.5K
Adrenergic Receptors (Adrenoceptors): Classification
2.6K
Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
2.6K
Adrenergic Receptors: ɑ Subtype
1.5K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
1.5K
Adrenergic Agonists: Therapeutic Classification
799
Adrenergic agonists can be classified based on their therapeutic uses and mechanisms of action. They serve various purposes in clinical applications.
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
799

