通过脱水脂肪体输送系统提高枣种子的生物可访问性,并对大鼠的丸激素诱导的良性前列腺增生产生影响
Dina Mostafa Mohammed1, Tamer M El-Messery2, Denis A Baranenko2
1Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt.
Frontiers in nutrition
|January 5, 2024
概括
这项研究开发了功能性软奶酪,富含枣种子化合物 (DSP),封装在脂质体中. 这种创新的奶酪配方通过减少前列腺扩大和炎症,有效地减轻了大鼠的激素诱导的良性前列腺增生 (BPH).
科学领域:
- 食品科学与技术 食品科学与技术
- 营养保健品 营养保健品
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳制品,如软奶酪,提供健康益处,但缺乏可生物利用的化合物.
- 枣种子中的化合物 (DSP) 具有抗氧化特性,但需要改进的输送系统.
- 良性前列腺增生症 (BPH) 是老年男性常见的疾病,需要新的治疗策略.
研究的目的:
- 开发一种创新的软奶酪,富含枣种子化合物 (DSP),封装在脂质体中.
- 在大鼠模型中研究这种功能性食物在减轻激素诱导的良性前列腺增生 (BPH) 中的疗效.
主要方法:
- 用超声波辅助提取DSP,然后进行脂质体封装和脱水.
- 在不同度 (1-3% w/w) 的软奶酪中加入DSP脂质体.
- 在Sprague-Dawley大鼠8周内评估BPH参数,包括前列腺大小,生化标志物,激素水平,氧化应激和细胞因子.
主要成果:
- 超声波辅助提取产生了大量的DSP,具有显著的抗氧化活性.
- 在BPH大鼠中,DSP-脂质体补充软奶酪显著降低了前列腺体重和前列腺指数.
- 治疗抑制了炎症性细胞因子反应,抑制了IL-10的产生,并减少了脂质过氧化.
结论:
- 软奶酪中DSP的脂质体封装是一种创造功能性食品的可行方法.
- 这种功能性软奶酪在老鼠中表现出对BPH进展的预防性.
- 脂质体中DSP的增强生物可用性有助于观察到的抗BPH效应.
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