对饮食衍生的循环抗氧化剂,氧化应激和骨关节炎风险的遗传责任:孟德尔的随机化研究
Yidan Tang1,2, Xiaolin Xu1,2, Shuangyi Zhang1,2
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in nutrition
|January 5, 2024
概括
高水平的视网醇和白蛋白显示出对骨关节炎 (OA) 风险的保护作用. 这项门德尔随机化研究研究了循环抗氧化剂,氧化应激和OA发展之间的联系.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 氧化应激的生物标志物
背景情况:
- 饮食中产生的抗氧化剂,氧化应激和骨关节炎 (OA) 病原体之间的相互作用仍然不清楚.
- 目前关于循环抗氧化剂,氧化损伤指标和OA风险之间的因果关系的证据是模两可的.
研究的目的:
- 调查饮食衍生循环抗氧化剂,氧化应激生物标志物和OA风险之间的潜在因果关系.
- 使用双样本门德尔随机化 (MR) 来探索这些关联.
主要方法:
- 使用的单核酸多态 (SNP) 与循环中的抗氧化剂 (视网醇,酸盐等) 相关. 和氧化应激生物标志物 (白蛋白,胆红素等). 作为仪表变量.
- 使用逆变量权衡 (IVW) 作为主要的MR分析方法.
- 进行多变量MR (MVMR) 来评估BMI和吸烟的调解,并在结果数据库中进行元分析.
主要成果:
- 基因预测的绝对视网醇水平与关节骨质炎风险降低有关 (OR=0.40).
- 基因预测的白蛋白水平与降低的整体OA风险 (OR=0.80),部OA风险 (OR=0.75) 和膝盖OA风险 (OR=0.82) 有因果关系.
- MVMR表明,白蛋白对关节OA的保护作用独立于吸烟和体力活动,但可能受到BMI的影响.
结论:
- 研究结果表明,较高的流通水平的视网醇和白蛋白对OA有潜在的保护作用.
- 这些结果有助于理解营养,氧化应激和OA之间的复杂关系.
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