在高风险的前列腺癌中,前关节管分泌透
Ali Serdar Gözen1, Antonios Koudonas2, Samet Senel3
1Department of Urology Medius Kliniken Ruit Ostfildern Germany.
BJUI compass
|January 5, 2024
概括
前关节管透 (VD) 在高风险前列腺癌 (PCa) 中是罕见的,仅发生在0.6%的患者中. 这种罕见的发现与高度侵略性的疾病有关,这表明了晚期PCa传播的潜在途径.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 高风险前列腺癌 (PCa) 需要对潜在的传播进行彻底评估.
- 了解PCa局部扩散的途径对于准确的分期和治疗计划至关重要.
- 管 (VD) 是PCa转移的潜在途径,但透模式需要进一步调查.
研究的目的:
- 确定前关节透 (VD) 在高风险前列腺癌 (PCa) 中的患病率.
- 评估腹膜前静脉透的临床意义和预后价值.
- 调查高风险PCa患者的静脉透和疾病特征之间的关系.
主要方法:
- 对332名接受机器人辅助激进前列腺切除术的高风险PCa患者进行前性研究.
- 对远距离和腹膜前分泌管 (VD) 段的组织学分析.
- 静脉疾病透状态与手术前和手术后疾病特征的相关性,包括布里甘蒂评分和病理发现.
主要成果:
- 在0.6%的患者中发现了前关节神经管 (VD) 透;在6%的患者中发现了远端VD透.
- 患有腹膜前静脉透的患者具有高度侵略性的,局部晚期的疾病和双边远端静脉透.
- 在pT3b患者中,远端静脉透没有显示与积极的外科边缘或结节状况的关联.
结论:
- 前关节管 (VD) 透是高风险前列腺癌 (PCa) 的罕见但重要的发现.
- 这种透模式可能代表PCa局部扩展的一个中间步骤,可能与罕见的丸复发有关.
- 如果有精液囊卷入,单独的远端静脉透可能不会赋予额外的预后价值.
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