丸激素会影响中性粒细胞的I型/II型干扰素反应,而这种干扰素在肝脏的阿米比亚सिस期间会影响中性粒细胞的反应
Marco Er-Lukowiak1, Sonja Hänzelmann2,3,4, Moritz Rothe1
1Molecular Parasitology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Frontiers in immunology
|January 5, 2024
概括
中性粒细胞的性别差异会影响肝硬化结局. 男性中性粒细胞不太成熟和响应,丸激素加剧了这种情况,这表明它在疾病易感性方面发挥了作用.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 医学中的性别差异.
背景情况:
- 由Entamoeba histolytica引起的肝脏虫病在男性中更为普遍.
- 天生的免疫细胞,特别是中性粒细胞,在阿米比亚सिस期间与肝损伤有关.
- 性激素,像雄激素一样,可能会影响免疫细胞功能和疾病结果.
研究的目的:
- 为了研究性和雄激素在中性粒细胞功能中的作用,在肝脏阿米比亚सिस.
- 为了比较雄性和雌性小鼠和人类之间的中性粒细胞特征和反应.
- 阐明丸激素对中性粒细胞成熟和激活的影响.
主要方法:
- 在Entamoeba histolytica感染期间对雄性和雌性小鼠中性粒细胞的比较分析.
- 评估中性粒细胞激活状态,基因表达 (干扰素刺激基因 (ISG)) 和信号通路.
- 在体内和体外实验,包括治疗和人类中性粒细胞刺激.
- 在中性粒细胞中测量viperin/RSAD2蛋白表达.
主要成果:
- 肝脏中的中性粒细胞积累在雄性小鼠中较高,并且随着治疗而增加.
- 与女性相比,男性中性粒细胞表现出不成熟的特征,减少了类似N1的表型,以及较低的ISG表达.
- 雌性中性粒细胞表现出更高的viperin/RSAD2表达,而这种表达是由降低的.
- 与女性中性粒细胞相比,人类男性中性粒细胞在体外产生较少的RSAD2.
结论:
- 性别特定的中性粒细胞生理学,包括成熟和I型干扰素响应性,影响肝脏阿米比亚सिस.
- 雄激素,特别是,可能抑制中性粒细胞的激活,并导致男性的敏感性增加.
- 这些发现突出了在阿米比亚सिस中调节中性粒细胞功能的潜在治疗点.
更多相关视频
08:26Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
12.1K
08:19Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
6.0K
相关概念视频
01:23Antimicrobial Proteins
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
01:26Testosterone: Functions and Regulation
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
01:30Inhibitors of Viral Protein Synthesis
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...