在撒哈拉以南非洲利用癌症免疫疗法
Elizabeth Olatunji1, Saloni Patel1, Katy Graef2
1Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Frontiers in oncology
|January 5, 2024
概括
预计到2040年,撒哈拉以南非洲的癌症死亡人数将翻一番. 这项研究揭示了医疗保健提供者中免疫疗法使用率和培训水平较低,突出了改善获得和教育的迫切需要,以应对不断增长的癌症负担.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 癌症研究 癌症研究
背景情况:
- 预计到2040年,撒哈拉以南非洲 (SSA) 的癌症死亡人数每年将超过100万.
- 晚期癌症,通常用免疫疗法治疗,影响近70%的SSA患者.
- 目前在SSA中免疫治疗的使用情况没有得到充分的记录,因此需要对区域基础设施和资源进行评估.
研究的目的:
- 评估撒哈拉以南非洲癌症免疫治疗的现状.
- 评估SSA的医疗保健提供者之间与免疫疗法相关的可访问性,使用,知识和培训.
主要方法:
- 开发了一项Qualtrics调查,并将其在线分发给SSA的3,231名医疗保健提供者.
- 该调查包括22个问题,重点关注免疫疗法基础设施,管理,知识和培训.
- 通过使用微软Excel收集和分析了来自28个南非国家和地区的292个医疗保健提供者的回答.
主要成果:
- 只有29%的受访者报告容易获得癌症免疫疗法,46%的人目前正在实践它.
- 免疫治疗反应的生物标志物测试是有限的,12%使用瘤突变负担,44%使用PD-L1.
- 46%的受访者表示他们熟悉免疫疗法,只有11%的受访者接受了免疫疗法的适当培训.
结论:
- 免疫治疗的使用和SSA的培训不足以应对日益增长的癌症负担.
- 增加获得免疫疗法药物和生物标志物测试的机会对于扩大其使用至关重要.
- 将免疫疗法培训纳入持续医学教育是SSA医疗保健提供者必不可少的.
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