在COVID-19康复患者中,与 Sarcoidosis 相关的自身免疫炎症
Artem Rubinstein1,2, Igor Kudryavtsev1,2,3, Annа Malkova4
1Almazov National Medical Research Centre, Saint Petersburg, Russia.
Frontiers in medicine
|January 5, 2024
概括
感染COVID-19可能会引发自身免疫性疾病,包括沙尔科发病. 本综述检查了SARS-CoV-2感染后免疫系统的变化及其与患者沙尔科毒症发展的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 病毒学 病毒学
背景情况:
- 越来越多的报道将COVID-19与新的自身免疫性疾病联系起来.
- 在COVID-19后的综合征中观察到类似肉类颗粒瘤.
- 理论上,sarcoidosis是由自身免疫系统引起的.
研究的目的:
- 调查沙尔科毒症和SARS-CoV-2感染中的适应性幽默免疫反应变化.
- 确定COVID-19是否可以引发沙尔科毒症的发病.
- 在这两种条件下分析免疫细胞和自身抗体概况.
主要方法:
- 对肉病和COVID-19的淋巴细胞器官组织学变化的审查.
- 对B细胞亚种群,T卵泡辅助细胞 (Tfh) 和T卵泡调节细胞 (Tfr) 的分析.
- 检查在类菌病和COVID-19后的疾病中存在的自身抗体.
主要成果:
- 在淋巴细胞组织中观察到沙尔科毒症和COVID-19之间的组织学相似之处.
- 在两种病理中观察到的B细胞,Tfh和Tfr细胞种群的变化.
- 各种自身抗体的存在表明共享的自身免疫成分.
结论:
- 感染SARS-CoV-2可能会诱导自身免疫反应.
- COVID-19可能会导致受影响个体的类菌病的发展.
- 在SARS-CoV-2感染后免疫调节失调,需要进一步调查自身免疫连续症.
相关概念视频
01:29Autoimmune Disorders
443
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
443
01:20COPD: Pathogenesis and Clinical Features
279
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
279
01:29Pneumonia II: Pathophysiology
279
The pathophysiology of pneumonia involves the following steps:
279
01:29Pulmonary Tuberculosis I
244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244
01:38Inflammation
53.4K
Overview
53.4K
01:28Pulmonary Tuberculosis II
240
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
240