三甘油-葡萄糖指数和甲状腺激素之间的相互作用,冠状动脉疾病的风险在患有甲状腺功能减弱的患者
Li Li1, Gaojun Cai1, Wei Lu1
1Department of Cardiology, Wujin Hospital Affiliated to Jiangsu University, The Wujin Clinical College of XuZhou Medical University, Changzhou, Jiangsu, China.
Frontiers in endocrinology
|January 5, 2024
概括
甘油三糖 (TyG) 指数和甲状腺激素 (THs) 相互作用,影响冠状动脉疾病 (CAD) 风险. 较低的TyG指数与较高的FT3水平提供了对CAD的保护.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 甘油三糖 (TyG) 指数是糖尿病前期,糖尿病和冠状动脉疾病 (CAD) 的公认标志物.
- 泰格指数和甲状腺激素 (THs) 对无甲状腺患者的CAD风险的综合影响需要进一步研究.
研究的目的:
- 为了研究TyG指数和THs在euthyroid受试者之间的关联.
- 评估TyG指数和THs对发展CAD的风险的独立和联合影响.
主要方法:
- 分析了一组1,297名无甲状腺患者,包括893名患有CAD和404名对照.
- 线性回归模型评估了TyG指数与THs (FT3,FT4,TSH) 之间的关联.
- 多变量逻辑回归分析了TyG指数和THs与CAD风险的相互作用.
主要成果:
- 血清FT3和FT4水平的降低独立地与TyG指数的升高有关.
- 较低的TyG指数与较高的FT3水平相结合,显示出对CAD的保护作用 (OR = 0.536).
- 较高的TyG指数,无论FT4水平如何,都显著增加了CAD风险 (ORs从1.656到1.920不等).
结论:
- 泰格指数是独立和负相关的FT3和FT4水平在euthyroid个体.
- 在TyG指数和THs之间存在显著的相互作用,影响CAD的风险.
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