在患有自闭症谱系障碍的儿童中,视网膜质细胞层,内状层和胸腔厚度的减少
Mahmut Zabit Kara1, Mehmet Hamdi Örüm2, Ayşe Sevgi Karadağ3
1Child Adolescent Psychiatry, University of Health Sciences, Antalya, TUR.
Cureus
|January 5, 2024
概括
自闭症谱系障碍 (ASD) 与减少的内状层 (IPL),状细胞层 (GCL) 和胸腔厚度有关. 这些发现表明,GCL可能是ASD中大脑结构变化的关键生物标志物.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 研究眼部生物标志物可能会为ASD病理生理学提供见解.
研究的目的:
- 在患有ASD的儿童中评估视网膜神经纤维层 (RNFL),胆道层,内状层 (IPL) 和状细胞层 (GCL).
- 为了比较ASD儿童和健康对照之间的这些眼睛参数.
- 评估临床测量 (CARS) 和OCT发现之间的相关性.
主要方法:
- 光谱相干断层扫描 (OCT) 用于测量RNFL,GCL,IPL和胸腔厚度.
- 分析了40名患有自闭症儿童和40名健康对照组的队列.
- 儿童自闭症评分表 (CARS) 用于评估ASD严重程度.
主要成果:
- 与对照人群相比,患有自闭症的儿童在两只眼睛中显著减少了胸膜厚度,GCL和IPL.
- 在左眼的特定区域发现了RNFL差异.
- 在CARS得分和左侧GCL/IPL体积之间发现了显著的相关性.
结论:
- 显著减少IPL,GCL和胸腔厚度是ASD的特征,与RNFL不同.
- 在ASD中,GCL可能作为结构性大脑恶化的更关键生物标志物.
- 图像 OCT 具有诊断和监测自闭症临床过程的潜力.
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