为成功治疗癌症进行基因检测
Desh Nidhi Singh1, Sushma Daripelli2,3,4, Mohamed Osman Elamin Bushara5
1Microbiology, Rama Medical College Hospital & Research Centre, Kanpur, IND.
Cureus
|January 5, 2024
概括
癌症遗传测试可以预测无症状个体的未来癌症风险,从而使积极的预防和治疗策略成为可能. 了解感知风险对于知情的遗传咨询和医疗保健决策至关重要.
科学领域:
- 在瘤学瘤学.
- 医学遗传学 医学遗传学
- 预防医学 预防医学
背景情况:
- 癌症遗传检测评估遗传标记,以预测无症状个体未来的癌症易感性.
- 遗传性癌症倾向强调了对家庭成员进行基因检测的重要性.
- 精度和负担能力的进步正在彻底改变癌症监测和治疗.
研究的目的:
- 在癌症遗传学中探索个体对癌症风险的看法.
- 审查癌症遗传风险的认识,知识和沟通.
- 检查遗传癌症综合征的基因检测,包括挑战和局限性.
主要方法:
- 关于癌症遗传检测的综合文献综述.
- 对感知癌症风险和遗传咨询的研究分析.
- 探索遗传测试中的意识,知识,风险沟通和挑战.
主要成果:
- 对癌症易感基因的知识增加推动了预测性遗传测试.
- 在遗传咨询中,感知风险至关重要,需要对益处和风险提供全面的信息.
- 意识,知识,风险沟通和挑战是癌症遗传测试的关键方面.
结论:
- 基因检测为癌症预防和治疗提供了变革性的潜力.
- 有信息的决策需要清楚地了解基因测试的好处和缺点.
- 持续的研究对于应对挑战和优化癌症遗传检测的使用至关重要.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Survival Analysis
355
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
355
Cancer Vaccines
370
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
370


