传染性脑炎的结果和后果
Kathryn A Kvam1, Jean-Paul Stahl2, Felicia C Chow3,4
1Department of Neurology & Neurological Sciences, Center for Academic Medicine, Stanford University, Stanford, CA, USA.
Journal of clinical neurology (Seoul, Korea)
|January 5, 2024
概括
传染性脑炎往往导致持久的认知和神经障碍. 虽然一些症状可能会随着时间的推移而改善,但长期关于后果的数据仍然有限,需要进一步研究.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 急性传染性脑炎是一种已知的临床综合征,具有显著的,但往往被忽视的,即时和延迟的后果.
- 尽管它有悠久的历史,但传染性脑炎后的连续和持续症状的全谱仍然没有得到充分的研究.
研究的目的:
- 审查和描述因传染性脑炎住院后几个月到几年经历连续和持续症状的患者的临床情况.
- 整合各种传染性脑炎病因后的认知,精神,神经,功能和生活质量结果的现有数据.
主要方法:
- 对病例系列数据进行了叙事性审查,重点关注传染性脑炎后的后果.
- 在PubMed中搜索了由赫尔佩斯病毒,弗拉维病毒,阿尔法病毒和尼帕病毒引起的脑炎的研究.
- 分析了41项涉及3072名成年患者的研究数据,评估了五个领域的结果:认知,精神,神经,全球功能和生活质量.
主要成果:
- 大多数患者退院时都出现障碍,经常表现出诸如记忆丧失和注意力障碍等认知缺陷.
- 后续症状在感染弗拉维病毒或尼帕病毒脑炎后的几年内有改善的趋势.
- 对于由其他传染性脑炎病原体引起的后果,长期结局数据很少.
结论:
- 传染性脑炎经常导致持续的损伤,影响患者健康和功能的多个领域.
- 迫切需要进一步的研究,以全面了解后续的程度.
- 为了有效的患者管理,需要标准化的评估方法和康复疗效的评估.
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