释放潜力:固体SNEDDS和冷凝固体分散的协同效应,以增强稳定性属性
Ahmad Yousef Tashish1,2, Ahmad Abdul-Wahhab Shahba1,2, Fars Kaed Alanazi1,2
1Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. BOX-2457, Riyadh-11451, Saudi Arabia.
Frontiers in bioscience (Landmark edition)
|January 5, 2024
概括
这项研究开发了一种新的固体自纳米乳化药物递送系统 (S-SNEDDS),与固体分散 (SD) 结合,以改善肉 (CN) 的稳定性和溶解. 该配方有效地增强了药物的溶解,并保持了难溶药物的稳定性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 配方科学科学 配方科学
背景情况:
- 自行纳米乳化药物递送系统 (SNEDDS) 是有效的基于脂质的配方,但在液体形式面临难以溶解药物的挑战.
- 将SNEDDS固化为S-SNEDDS增强了稳定性,但可能会阻碍药物溶解.
- 开发一个结合的S-SNEDDS和固体分散 (SD) 方法是为了克服这些局限性的.
研究的目的:
- 设计一种无药物固体S-SNEDDS与固体分散 (SD) 相结合.
- 为了提高肉素 (CN) 的储存稳定性.
- 为了维持或改善从固体剂型中溶解CN的药物溶解.
主要方法:
- 无毒液体SNEDDS使用Neusilin® US2.2进行了固化.
- 辛纳瑞固体分散剂 (CN-SDs) 是通过冷干燥制备的.
- 描述包括SEM,DSC,XRD和FTIR;进行了体外脂解研究.
主要成果:
- 在冷干燥固体分散系统 (FD-SD) 中,FTIR证实了CN的无形化.
- 在体外脂解过程中,S-SNEDDS + SD组合在溶液中保持了显著的CN.
- 加速稳定性研究显示96%的完整无形CN和>90%的释放在pH 1.2 6个月.
结论:
- 开发的无药S-SNEDDS + SD配方增强了辛纳的溶解.
- 这种方法为改善弱基药物的稳定性和溶解提供了一个潜在的策略.
- 该配方解决了稳定性限制,同时改善了药物释放特性.
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