铜催化不对称合成 - 类固醇本佐西醇
Wan-Er Gan1, Yong-Shun Wu1, Bin Wu1
1College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Key Laboratory of Organosilicon Material Technology of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, P. R. China.
铜催化使得通过分子内合,类固醇氧的不对称合成成为可能. 这种方法可以高效地为各种应用制造性化合物和功能化.
科学领域:
- 有机化学 有机化学
- 不对称的催化剂.
- 合成有机化学 合成有机化学
背景情况:
- 类固醇化合物是材料科学和药物化学中有价值的构建模块.
- 在合成化学中,开发高效的方法来制造质纯的有机素仍然是一个重大挑战.
研究的目的:
- 开发一种-类固醇索的铜催化不对称合成.
- 探索以碳和两种立体中心访问奇拉性索西的动态分辨率.
- 为了证明性索西醇在合成富含的功能化四氧化物西醇中的实用性.
主要方法:
- 由铜 (I) /二化催化的[2-[基甲基]]的分子内Si-O合.
- 使用铜 (I) /PyrOx (皮里丁-奥克萨林连接体) 的赛门 [2-基甲基) ] 锡兰的动态分辨率.
- 性佐西醇与有机和格林纳德试剂的环开反应.
主要成果:
- 通过Cu-催化分子内Si-O合,实现了-类固醇佐西醇的不对称合成.
- 鉴定了Cu (I) /difluorphos作为一种有效的系统,用于对抗选择性Si-C键裂解和Si-O键形成.
- 开发了一种使用Cu(I) /PyrOx的动力分辨率协议,以产生碳和类固醇氧.
- 通过开环的奇拉本佐克西醇合成各种丰富的功能化四氧化物.
结论:
- 建立了一种新的Cu催化不对称合成和动力分辨率,用于类固醇索.
- 证明了开发的方法的多功能性,以获取有价值的性有机化合物.
- 提供了一条从奇拉性佐沙醇中合成富含酵素的功能化四基有机基素的途径.
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