铜同位素组成测量使用蓝宝石双路径MC-ICPMS与碰撞/反应细胞
Tu-Han Luu1, Daniel Peters2, Esther Lahoud1
1Université Paris Cité, Institut de Physique du Globe de Paris, CNRS, F-75005 Paris, France.
Analytical chemistry
|January 5, 2024
概括
这项研究引入了一种新的方法,用于精确的铜 (Cu) 同位素测量,使用一个碰撞/反应细胞诱导合等离子体质谱仪. 该技术有效地消除干扰,使高 (Na) 含量生物样本能够准确分析.
科学领域:
- 地质化学 地质化学
- 分析化学 分析化学
- 生物地质化学生物地质化学
背景情况:
- 铜 (Cu) 同位素测量对于理解生物和地质过程至关重要.
- 生物样本中的高 (Na) 含量在传统质谱学中会产生等离子干扰 (例如,40Ar23Na+在63Cu+上).
- 尽量减少样本准备对于分析大型生物数据集至关重要.
研究的目的:
- 开发和验证一种新的方法,用于准确的Cu同位素测量,使用一个碰撞/反应细胞多采集器感应合等离子质谱仪 (CRC-MC-ICPMS).
- 在CRC中评估He-H2气体混合物的有效性,以消除基于Na的干扰.
- 减少在Cu同位素分析中需要进行广泛的化学分离,特别是对于生物样本.
主要方法:
- 使用了Nu Sapphire多采集器诱导合的血源质谱仪与碰撞/反应电池 (CRC-MC-ICPMS).
- 在CRC中引入He-H2气体混合物以解决40Ar23Na+干扰在63Cu+上的干扰.
- 在各种样本中分析了Cu同位素组成 (δ65Cu),包括纯Cu标准,小鼠大脑和生物标准 (金枪鱼,人体血清),具有不同的Na/Cu比率.
主要成果:
- 精确的 δ65Cu值可以在高达~65的Na/Cu比率的样本中获得,即使Cu度低 (100ppb).
- 证明了 δ65Cu.的良好的短期重复性 (0.05‰) 和长期外部可重复性 (0.07‰)
- 通过将结果与传统方法进行比较,验证了该方法,并显示了生物样本的精确测量,使用最小的化学处理.
结论:
- 使用He-H2气体混合的CRC-MC-ICPMS方法为精确的Cu同位素测量提供了强大的和高效的方法.
- 这种技术显著简化了样品的准备,使得它非常适合分析具有高Na/Cu比率的复杂生物矩阵.
- 开发的方法提高了不同科学领域的Cu同位素分析的可靠性和吞吐量.
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