非癌症疾病的放射治疗:长期的益处和风险
Juliette Thariat1,2, Mark P Little3, Lydia B Zablotska4
1Department of Radiation Oncology, Comprehensive Cancer Centre François Baclesse, Caen, France.
International journal of radiation biology
|January 5, 2024
概括
放射治疗对心室动脉冲动等非癌症疾病有前途,但需要对阿尔茨海默病和COVID-19肺炎等疾病进行进一步研究,平衡好处与长期风险.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 临床医学 临床医学
背景情况:
- 从历史上看,离子辐射在恶性瘤以外的非癌症条件下被探索.
- 最近的兴趣已经恢复了非癌症疾病的放射治疗应用,包括耐火性心室动脉冲动,神经退行性疾病和COVID-19肺炎.
- 一些国家有骨关节炎和退行性骨/关节疾病的历史迹象.
研究的目的:
- 审查在非癌症疾病中使用放射治疗的生物学理由.
- 概述正在进行的临床前和临床研究,研究非癌症疾病的放射治疗.
- 讨论提出的理由的合理性,并考虑长期的辐射风险.
主要方法:
- 现有文献的叙述性审查.
- 在非癌症疾病中进行放射治疗的生物学理由的分析.
- 检查正在进行的临床和临床前研究数据.
主要成果:
- 放射治疗在心室动脉冲动下表现出一些有益的效果.
- 目前,有限的证据支持用于阿尔茨海默病和COVID-19肺炎的放射治疗.
- 剂量范围从0.5-25 Gy,分为单个或多个分数.
结论:
- 放射治疗在非癌症疾病中的作用是复杂的,它就像一把双刃剑.
- 虽然它在关键情况下对心室动脉冲动有效,但其用于其他非癌症疾病的使用需要进一步证明.
- 优化辐射剂量以准患病组织,同时最大限度地减少对健康组织的暴露,对于未来的应用至关重要.
相关概念视频
Biological Effects of Radiation
15.5K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.5K
Radiological Investigation III: Pulmonary Angiogram and PET Scan
93
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
93
Radiological Investigation I: X-ray and CT
241
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
241
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Isotopes and Radioisotopes
8.6K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
An isotope containing...
8.6K
X-ray Imaging
5.5K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
5.5K


