布洛芬用于治疗儿童急性术后疼痛
Sara Pessano1, Natasha R Gloeck2, Luca Tancredi3,4
1Pediatric Clinic and Endocrinology Unit, IRCCS Istituto G. Gaslini, Genoa, Italy.
The Cochrane database of systematic reviews
|January 5, 2024
概括
布洛芬有效地管理儿童的急性术后疼痛,与安慰剂和青相比,减少疼痛强度. 然而,证据的确定性各不相同,需要更多关于儿童疼痛管理的安全性和最佳剂量策略的研究.
科学领域:
- 儿科麻醉学和疼痛管理
- 药理学和治疗学 药理学和治疗学
- 基于证据的医学基于证据的医学.
背景情况:
- 有效的疼痛管理对于儿童的康复和手术后的生活质量至关重要.
- 布洛芬是一种非类固醇抗炎药物 (NSAID),通常用于儿科患者的术后疼痛和炎症.
研究的目的:
- 评估易布洛芬治疗儿童急性术后疼痛的疗效和安全性.
- 为了比较布洛芬与安慰剂和其他活性止痛药.
- 分析不同类型的布洛芬剂量,输送途径和输送策略.
主要方法:
- 对43项随机对照试验 (RCT) 的系统综述和元分析,涉及3935名儿童 (17岁及以下).
- 在多个数据库 (CENTRAL,MEDLINE,Embase,CINAHL) 搜索到2023年8月.
- 主要结局包括儿童报告的疼痛缓解,疼痛强度,不良事件和严重不良事件,分析使用风险比率和标准化平均差异.
主要成果:
- 与安慰剂 (中度确定性证据) 相比,ibuprofen可能会在干预后两小时内减少儿童报告的疼痛强度.
- 与甲相比,ibuprofen可能会在两小时内减少疼痛强度,并且可能在干预后24小时内提供轻微的减轻 (中度至低确定性证据).
- 与吗啡相比,ibuprofen可能会减少不良事件,但与安慰剂或青相比,不良事件或出血的差异很小 (中度至低确定性证据).
结论:
- 与安慰剂和青相比,布洛芬在减少儿童急性术后疼痛方面是有效的,特别是在短期内.
- 由于研究报告和进行的局限性,与其他止痛药相比,依布洛芬的安全概况和最佳管理仍然存在重大不确定性.
- 需要进一步进行高质量的研究,以澄清儿科术后疼痛管理中各种布洛芬疗法的安全性和有效性.
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