在过度活动的膀患者中尿液浸泡的特征和治疗
B Capdevila Vilaró1, I Casal-Beloy2, F N Villalón Ferrero3
1Pediatric Surgery Department. Hospital Sant Joan de Déu. Barcelona (Spain).
概括
大多数过度活动膀 (OAB) 儿童患有一次性尿液 (PE),这解释了白天膀治疗的反应不佳. 二次性尿尿失禁 (SE) 患者的治疗结果显著改善,突出需要准确的尿尿失禁类型表征.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 过度活跃的膀研究
- 尿尿失禁的治疗方法
背景情况:
- 过度活跃的膀 (OAB) 是儿童常见的病症,常常伴有尿液浸泡.
- 了解不同类型的尿尿症对于有效的OAB管理至关重要.
- 之前的研究还没有完全阐明OAB患者基于尿尿症类型的治疗反应.
研究的目的:
- 定义和区分儿科过度活动膀患者的尿液浸泡类型.
- 为了评估白天膀治疗的反应,在患者与初级尿尿失禁 (PE) 与二次尿尿失禁 (SE).
- 为了确定对白天膀治疗的完整尿液反应 (CER) 的预测因素.
主要方法:
- 一项前性多中心研究,涉及152名OAB患者,从2019年到2021年患有尿.
- 患者接受了抗胆固醇药或神经调节3个月.
- 收集的数据包括空白日历,儿科下泌尿道评分系统 (PLUTSS) 评分和尿特定变量,将患者分为PE和SE组.
主要成果:
- 在152名OAB患者中,有109名 (71.7%) 患有尿液浸泡,其中73.3%被归类为PE,26.7%被归类为SE.
- 与PE患者相比,二次尿尿症 (SE) 患者的部分尿液反应 (PER) (55.2%对15%) 和完全尿液反应 (CER) (48.3%对5%) 的比率显著更高.
- 多变量分析显示,与PE患者相比,SE患者对白天膀治疗的反应概率增加了50倍 (OR:49.79).
结论:
- 大多数OAB儿童患有初级尿液 (PE),与典型的白天膀治疗反应不佳有关.
- 二次性尿泡症 (SE) 显示出明显更好的治疗反应,这表明有不同的潜在机制.
- 准确地描述OAB儿童的尿类型对于定制适当和有效的治疗策略至关重要.
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