颗粒物暴露与慢性鼻炎中炎症性细胞因子和埃索诺菲尔的增加有关
Rory J Lubner1, Kolin Rubel1, Rakesh K Chandra1
1Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Allergy
|January 5, 2024
概括
暴露于细颗粒物 (PM2.5) 可能通过改变免疫反应导致慢性鼻炎 (CRS). 这项研究将PM2.5与特定的炎症模式以及CRS患者中喘和过敏性鼻炎风险的增加联系起来.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性鼻炎 (CRS) 的发病过程涉及复杂的宿主免疫,微生物群和环境相互作用.
- 关于细颗粒物 (PM2.5) 对CRS发展的影响的数据有限.
- PM2.5与其他呼吸道疾病有关,这表明它可能在CRS中发挥作用.
研究的目的:
- 研究CRS患者环境PM2.5暴露与炎症性细胞因子模式之间的关联.
- 探索PM2.5作为影响CRS病原性的潜在环境因素.
- 通过细胞因子分析了解环境暴露与CRS之间的机制联系.
主要方法:
- 分析了308名接受内镜外科手术的CRS患者的数据.
- 在手术内粘液中使用多重流细胞计量对细胞因子的量化.
- 时空机器学习模型用于估计手术前一年的每日PM2.5水平.
- 相关性和回归分析以评估细胞因子,PM2.5和临床因素之间的关系.
主要成果:
- 在几个炎症性细胞因子 (IL-2,IL-5/IL-13,IL-12,IL-21) 和平均手术前PM2.5水平 (6,9,12个月) 之间发现了显著的相关性.
- 经过对临床和人口统计学变量进行调整后,这些关联仍然存在.
- 增加的PM2.5暴露与喘和过敏性鼻炎的更高几率,以及增加的组织乙氨基细胞数量有关.
结论:
- 长期暴露于PM2.5可能是CRS的独立风险因素.
- 暴露于PM2.5与CRS中的2型主导炎症反应有关.
- 像PM2.5这样的环境因素在CRS的发展和严重性方面发挥着重要作用.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:20Asthma: Pathogenesis and Management
405
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
405
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:17Drugs Used in Lower Respiratory Disorders: Overview
445
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
445