为风湿性关节炎风险人群提供综合性非药物治疗
Javier Courel-Ibáñez1, Tomas Vetrovsky2, Nora Růžičková3
1Department of Physical Education and Sport, University of Granada, C/Camino de Alfacar, 21, 18071, Granada, Spain. courel@ugr.es.
Rheumatology international
|January 5, 2024
概括
识别患有类风湿性关节炎 (RA) 风险的个体为早期干预提供了机会. 本综述探讨了非药理学策略,以潜在地预防风险人群的RA发病.
科学领域:
- 类风湿病学 类风湿病学
- 预防医学 预防医学
- 免疫学 免疫学 免疫学
背景情况:
- 在临床症状出现之前,可以预测类风湿性关节炎 (RA) 的进展.
- 在RA的临床前阶段为预防疾病发病的干预提供了一个关键的窗口.
- 目前,有限的证据支持对延迟或停止RA表现的干预措施.
研究的目的:
- 为风险较高的个人提供非药物治疗的全面概述.
- 在临床前RA中探索可修改的因素,以实现综合性,非药物治疗方法.
- 审查针对性干预的RA临床表现之前的机制.
主要方法:
- 现有关于危险人群非药物干预的文献的叙述性综述.
- 探索生活方式因素 (吸烟,饮食,运动,牙健康) 和它们的影响.
- 对潜在机制的分析,包括表观遗传学,自身抗体,细胞因子和微生物组.
主要成果:
- 药理干预可以逆转亚临床炎症并延迟RA发病.
- 针对可修改因素的生活方式修改可能会改善风险人群的预后.
- 多学科干预措施在阻止RA表现的有效性仍未确定.
结论:
- 建议在高危人群中采用结合药理和非药理策略的综合性多因素方法.
- 针对生活方式因素的非药物干预措施有望改善RA预后.
- 需要进一步的研究,以确定多学科干预措施在预防RA发作的好处.
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