风险因素与认知之间的关系的规模和方向取决于年龄:对5项基于社区的研究进行了综合分析
Osorio Meirelles1, Anthony Arnette1, Vilmundur Guðnason2,3
1Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, 251 Bayview Blvd., Baltimore, MD, 21224, USA.
European journal of epidemiology
|January 5, 2024
概括
心血管风险因素与认知能力下降有关,但随着年龄的增长,这种联系会减弱. 然而,透静血压的血压.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 关于心血管风险因素 (CVRF) 和认知障碍的现有研究显示出混合的结果.
- 与年龄相关的混可能解释了研究中检查CVRF-认知功能联系的差异.
研究的目的:
- 调查CVRF与认知功能 (数字符号替换测试;DSST) 之间的关联如何在整个生命周期中发生变化.
- 确定年龄是否会改变CVRF与认知表现之间的关系的强度和方向.
主要方法:
- 在五个潜在队列中,从30,967名参与者 (年龄在42-96岁之间) 的个人数据中进行了汇总和协调.
- 分析的CVRF包括静缩血压,静缩血压,总胆固醇,禁食葡萄糖和体重指数.
- 采用线性和二进制零碎回归模型来评估CVRF和DSST分数之间的关联的年度变化.
主要成果:
- 较高的CVRF通常与较低的DSST表现相关,表明认知功能较差.
- 这种关联的强度随着大多数CVRF的年龄增加而减弱到零.
- 扩张压血压显示出一种独特的模式,在晚年,这种关联从负向正转变.
结论:
- 年龄是一个关键因素,不仅驱动认知衰退,而且调节CVRF-认知功能关系.
- 观察到的CVRF与认知功能之间的关系的年龄相关变化可能解释了先前研究中不一致的发现.
- 了解这些特定年龄的动态对于准确评估与认知健康相关的心血管疾病风险至关重要.
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