尼亚摄入量与膝关节骨关节炎疼痛和功能之间的关联:一个纵向队列研究
Zitian Zheng1,2, Huanhuan Luo3,4, Qingyun Xue5,6,7
1Department of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Da Hua Road, DongDan, Beijing, 100730, P.R. China.
Clinical rheumatology
|January 5, 2024
概括
增加素摄入量与膝关节骨关节炎疼痛减少和功能改善有关. 包括中年女性在内的特定群体可能会获得更大的好处,提高整体生活质量.
科学领域:
- 营养科学 营养科学
- 类风湿病学 类风湿病学
- 生物化学 生物化学
背景情况:
- 尼亚 (维生素B3) 作为NAD (P) +的前体,起着至关重要的作用,支持细胞能量代谢.
- 尼亚具有与骨关节炎相关的抗炎,止痛和抗氧化特性.
- 了解氨酸对膝关节骨关节炎 (OA) 严重程度的影响对于治疗策略至关重要.
研究的目的:
- 调查饮食中素摄入量与膝关节骨关节炎 (OA) 严重程度之间的关联.
- 评估尼亚对膝盖骨关节炎患者疼痛和功能能力的影响.
- 为了确定特定的患者亚组,这些患者可能会从增加的氨酸消费中获益更多.
主要方法:
- 基于人口的骨关节炎倡议 (OAI) 队列的分析,具有放射性确认的膝盖OA.
- 使用食物频率问卷评估素摄入量.
- 使用膝关节损伤和骨关节炎结局得分 (KOOS) 和WOMAC指数对膝关节OA症状的评估.
- 使用一般化添加混合模型进行统计分析.
主要成果:
- 在48个月的时间内,观察到较高的氨酸摄入量与减少膝关节OA疼痛和功能限制之间存在显著的相关性.
- 改善的KOOS和WOMAC得分与增加的氨酸消费有关 (P <0.05).
- 特定的子组,包括中年人群,女性和肥胖个体,表现出更实质性的改善.
结论:
- 增加尼亚摄入量显著与减少膝盖骨关节炎患者的疼痛和改善功能有关.
- 尼亚补充剂有望提高膝关节骨质炎患者的生活质量.
- 分层分析表明,某些患者队列可能会从增加的氨酸消费中获得更大的治疗益处.
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