克西拉在美国各州的过量死亡和法医药物报告中,2019-2022年
Manuel Cano1, Raminta Daniulaityte2, Flavio Marsiglia1,3
1School of Social Work, Arizona State University, Phoenix.
JAMA network open
|January 5, 2024
概括
克西拉越来越多地出现在美国的过量死亡中,数据显示其在几乎所有州都有存在. 然而,全面的年度州级过量使用死亡数据仍然有限,阻碍了公共卫生反应.
科学领域:
- 公共卫生 公共卫生
- 法医科学 法医科学 法医科学
- 毒理学 毒理学 毒理学
背景情况:
- 克西拉是一种兽医镇静剂,在非法药物供应中越来越多地被检测到.
- 它在街头毒品中的存在和过量服用死亡是美国日益严重的公共卫生问题.
- 关于西拉与死亡事故有关的有限的州级数据阻碍了有效的本地反应.
研究的目的:
- 编制和分析现有的州级数据,以确定西拉对过量死亡的相关性.
- 评估不同州的法医药物报告中西拉的流行程度.
- 为了确定西拉监测中的地理趋势和数据缺口.
主要方法:
- 从2019-2022年使用二次数据分析进行横截面研究.
- 数据来源包括国家法医实验室信息系统 (NFLIS),国家卫生统计中心和州特定的法医/公共卫生报告.
- 分析的重点是每年与西拉相关的过量死亡和NFLIS药物报告人均和总报告的百分比.
主要成果:
- 在2019-2022年期间,至少有43个州报告了与雪拉相关的过量死亡.
- 仅有21个州的年度死亡率数据可用,2022年佛蒙特州和康涅狄格州的死亡率最高.
- 在NFLIS报告中Xylazine的代表性从2019年到2022年大幅增加,到2022年几乎在所有州出现.
结论:
- 克西拉在过量死亡和法医样本中的存在在美国各地很普遍,特别集中在东部州.
- 尽管其地理范围广泛,但仍然存在严重缺乏公开的年度州级过量使用死亡数据.
- 解决这些数据缺口对于告知和实施针对性公共卫生干预措施来防止与克西拉相关的危害至关重要.
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