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在以色列45岁时进行结肠直肠癌查:成本效益和全球影响

Elizabeth E Half^1,2, Zohar Levi^3,4, Ajitha Mannalithara⁵

¹Gastroenterology Institute, Rambam Health Care Campus, Haifa, Israel.

|January 5, 2024

概括

在以色列,在45岁开始进行结肠直肠癌 (CRC) 查,提供了适度的好处和可接受的成本. 建议制定统一的国家政策,为国际CRC查指南提供有价值的见解.

科学领域:

在瘤学瘤学.
公共卫生公共卫生
卫生经济学卫生经济学

背景情况:

结肠直肠癌 (CRC) 发病率在50岁以下的个人中正在全球范围内上升.
美国的CRC查开始年龄已降至45岁.
本研究评估了在以色列45岁开始CRC查的成本效益.

研究的目的:

评估在以色列45岁开始进行结肠直肠癌 (CRC) 查的成本效益.
为以色列国家查政策提供信息.
为解决有关CRC查年龄的国际相关问题.

主要方法:

使用以色列数据校准了一种经过验证的CRC查模型.
从45-74岁和50-74岁开始,每年进行一次便免疫化学检测 (FIT) 或每10年进行一次结肠镜检查.
分析了75岁时进行额外结肠镜检查的影响以及性别/种族的差异.

主要成果:

从50岁开始的查可将CRC发病率降低高达70%,死亡率降低高达77%.
在45岁开始查后,CRC发病率额外减少3%,死亡率减少2%.
在45岁时进行查的费用为FIT的23,800-53,900 NIS/QALYG和结肠镜的110,600-162,700 NIS/QALYG之间.

结论:

在以色列,在45岁开始进行CRC查,预计将以每QALYG可接受的成本提供适度的临床益处.
一个统一的国家查政策是有利的,尽管估计的性别和种族差异.
这些发现可以指导以色列的指导方针,并作为国际案例研究.

关键词:

结肠癌是什么意思结肠癌是什么意思结肠直肠癌是什么意思经济效益性经济效益性预防预防预防查年龄开始的开始

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