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Updated: Jul 6, 2025

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
08:53

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

364

在复制应激过程中,PRIMPOL产生的新生的DNA链不连续性的USP1依赖的核分解扩张

Alexandra Nusawardhana1, Lindsey M Pale1, Claudia M Nicolae1

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Nucleic acids research
|January 5, 2024
PubMed
概括

复制压力会造成DNA缺口,这些缺口会被MRE11和EXO1核酶扩大. 脱泛化酶USP1促进了这种扩张,导致DNA断裂和基因组不稳定.

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