川崎病与台湾的城市化程度和家庭特征的关联:使用国家一级数据的嵌套病例控制研究
Chung-Fang Tseng1, Hsiao-Chen Lin1, Chung-Yuh Tzeng2
1School of Public Health, Chung Shan Medical University, Taichung, Taiwan.
PloS one
|January 5, 2024
概括
川崎病 (KD) 的风险在患有KD的兄弟姐妹,年长的母亲和城市生活方式的孩子中更高. 相反,年轻的父母,更多的兄弟姐妹和较低的社会经济地位与KD风险降低有关.
科学领域:
- 儿科 儿科 儿科
- 流行病学 流行病学
- 心血管研究研究心血管研究
背景情况:
- 川崎病 (KD) 是一种严重的儿科炎性血管炎,原因不明.
- 它是5岁以下儿童获得冠心病的主要驱动因素.
- 了解KD的流行病学关联对于早期检测和预防至关重要.
研究的目的:
- 调查川崎病与台湾儿童的人口,家长和围产因素之间的关联.
- 确定幼儿KD发育的风险和保护因素.
主要方法:
- 一项嵌套病例对照研究利用了来自台湾健康与福利数据科学中心的数据.
- 包括2006年至2015年间出生的1,939,449名儿童,观察KD在5岁之前的发展.
- 条件后勤回归分析了关联,将KD病例与对照进行匹配 (8:1比).
主要成果:
- 较年轻的父母年龄 (<25岁) 与降低的KD风险有关 (母亲的OR=0.72,父亲的OR=0.68).
- 增加兄弟姐妹数量 (>2) 和较低的社会经济地位显示出保护作用.
- 兄弟姐妹的KD病史显著增加了风险 (OR=4.39),城市生活也是如此.
- 较年长的母亲年龄,高收入和较小的家庭规模与较高的KD发病率有关.
结论:
- 在5岁以下的儿童中,高川崎病发病率与城市环境,家族病史,母亲年龄较大,高收入和家庭规模较小有关.
- 较年轻的父母年龄,更多的兄弟姐妹和较低的社会经济地位似乎是保护性的.
- 没有发现父母的过敏或自身免疫疾病与KD风险有关.
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