系统性抗微生物治疗对有症状的奶牛便微生物群的影响
Rose M Collis1,2, Patrick J Biggs2,3,4, Sara A Burgess2
1AgResearch Ltd, Hopkirk Research Institute, Massey University, Palmerston North, New Zealand.
PloS one
|January 5, 2024
概括
乳牛的全身抗菌疗法可以在治疗期间减少肠道微生物群的多样性,但治疗后通常会出现恢复. 个体动物因素显著影响微生物组的变化和恢复,这对抗生素耐药性的发展有影响.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物健康 动物健康
- 微生物组研究 微生物组研究
背景情况:
- 抗微生物药物耐药性 (AMR) 是一个重要的全球健康问题,由抗微生物药物的滥用驱动.
- 抗菌疗法对细菌群落和牛的抗性产生影响.
- 关于全身抗菌疗法在疾病期间对奶牛便微生物群的影响的数据有限.
研究的目的:
- 评估系统性抗微生物治疗对牧场环境中的奶牛便微生物群的影响.
- 分析来自不同临床条件和抗微生物治疗的牛的便样本.
主要方法:
- 从接受全身抗菌药物治疗的奶牛身上取出的便样本进行分析.
- 在个体动物水平上评估微生物组的组成,多样性和丰富性.
- 隔离特定的细菌菌株,包括耐药的大肠杆菌.
主要成果:
- 抗菌治疗导致乳牛便中的细菌多样性和丰富性减少.
- 微生物群的多样性经常在治疗后恢复,个体动物因素是变化的关键驱动因素.
- 从接受治疗的奶牛中分离出产生AMpC的大肠杆菌,这表明AMR的潜在发展和传播.
结论:
- 系统性抗菌药物治疗显著扰乱牛便微生物群,恢复受到个体动物特征的影响.
- 抗菌素耐药性大肠杆菌的存在凸显了与牛中极其重要的抗菌素使用相关的风险.
- 减少极其重要的抗微生物药物的使用对于缓解AMR传播至关重要.
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