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组合的低分离放射治疗和 pembrolizumab 在无塑性甲状腺癌的甲状腺癌
Janice Ser Huey Tan1, Timothy Kwang Yong Tay2, Enya Hui Wen Ong3
1J Tan, Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.
European thyroid journal
|January 5, 2024
概括
这项研究探讨了将免疫疗法 (pembrolizumab) 与辐射疗法 (QUAD-shot RT) 结合起来,用于治疗无塑性甲状腺癌 (ATC). 治疗显示出有希望的反应率,并且耐受性良好,这表明ATC患者的长期存活潜力.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 辐射瘤学 辐射瘤学
背景情况:
- 无塑性甲状腺癌 (ATC) 是高度侵略性的,预后不佳.
- 现有的ATC疗法有效性有限,并且与治疗耐药性有关.
研究的目的:
- 评估pembrolizumab免疫疗法和低分离放射疗法 (QUAD-shot RT) 的联合疗法的疗效和安全性.
- 评估响应者对这种组合治疗的免疫反应.
主要方法:
- 一个由5名ATC患者组成的病例系列接受了QUAD-shotRT和pembrolizumab.
- 布罗利祖马布每3-4周服用一次,直到进展或24个月.
- 循环T细胞的免疫分析在一个受试者中进行.
主要成果:
- 随访时间中位数为32.6个月,在5名患者中观察到80%的整体应答率 (2CR,2PR).
- 两个完全响应者仍然没有疾病.
- 无进展生存时间的中位数为7.6个月;一年的PFS和OS率为40%.
结论:
- QUAD-shot RT和pembrolizumab的组合在高级ATC中表现出显著的活性.
- 两名患者实现了长期存活,这表明局部和全身治疗的潜在协同效应.
- 这种治疗方案需要在更大的患者队列中进行进一步的研究.
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