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Updated: Jul 6, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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在肠道中的IL-10mpting TH17细胞命运

Sarah Mann Danielson1, Kristine A Kuhn1

  • 1Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Science immunology
|January 5, 2024
PubMed
概括

洲际蛋白-10 (IL-10) 调节特定于小肠中的肠道微生物的T辅助细胞17 (TH17). 这种细胞因子对于维持免疫平衡和预防该区域的炎症至关重要.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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