商用大麻的化学成分 商用大麻的化学成分
David S Wishart1,2,3,4, Mickel Hiebert-Giesbrecht1, Gozal Inchehborouni1
1Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
Journal of agricultural and food chemistry
|January 5, 2024
概括
研究人员使用先进的代谢学和生物信息学编制了超过6000种大麻化学成分. 这种全面的数据现在可以在开放访问的大麻化合物数据库中获得,以帮助科学界.
科学领域:
- 药理学 药理学是指药理学的学科.
- 化学 化学 化学
- 生物信息学是一种生物信息学.
背景情况:
- 大麻被广泛用于医疗和娱乐目的,引起人们对其化学成分和生理作用的兴趣.
- 关于大麻化学的现有信息往往过时,并且在各种来源中分散.
- 需要一个全面的,最新的资源来支持大麻化合物的研究和理解.
研究的目的:
- 创建商用大麻中化学成分的综合数据库.
- 为了利用现代的代谢学和生物信息技术来收集数据.
- 为大麻研究社区提供一个集中,开放的资源.
主要方法:
- 使用了高分辨率和低分辨率液体染色学-质谱学 (LC-MS),气体染色学-质谱学 (GC-MS) 和感应合等离子体质谱学 (ICP-MS) 的组合.
- 采用计算机辅助文本挖掘和计算基因组规模的代谢推断来进行数据分析.
- 汇编的数据包括化合物描述,物理化学性质,生理效应和蛋白质标.
主要成果:
- 在商业大麻中识别和目录了6000多种化学成分.
- 将综合代谢学和生物信息学数据集成到结构化格式中.
- 开发了大麻化合物数据库 (https://cannabisdatabase.ca),作为一个公开可访问的资源.
结论:
- 大麻化合物数据库提供了大麻化学成分的集中式,开放式存储库.
- 该资源整合了关键信息,解决了更新和可访问的大麻化学数据的需求.
- 该数据库预计将大大有益于研究人员和更广泛的大麻社区.
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