关于上腺的最新消息 - - 仍然是一个
Philipp Augsburger1,2, Jani Liimatta1,2,3, Christa E Flück1,2
1Pediatric Endocrinology, Diabetology, and Metabolism, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
The Journal of clinical endocrinology and metabolism
|January 5, 2024
概括
上腺,上腺分泌的开始,需要对早产上腺 (PA) 进行新的定义,以确定有风险的儿童. 需要进一步的研究来了解上腺及其长期健康影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 人类发展 人类发展
- 副腎腺體的功能.
背景情况:
- 上腺是一个正常的发育阶段,上腺皮质在8-9岁左右增加了雄激素的产生.
- 过早上腺 (PA) 发生得更早,但其分子调节和长期健康后果在很大程度上是未知的.
- 目前PA是一种排除诊断,缺乏精确的诊断标准.
研究的目的:
- 审查当前关于上腺和过早上腺的知识.
- 突出需要修订定义和进一步研究上腺的机制和意义.
- 识别与上腺变异相关的不良健康结果的风险儿童.
主要方法:
- 在主要的科学数据库 (PubMed,ScienceDirect,Web of Science,Embase,Scopus) 中进行了全面的文献搜索.
- 搜索的重点是过去5年内发表的研究,使用关键词与上腺疼痛, pubarche 和上腺类固醇生成相关.
- 包括原创文章,评论和元分析来综合现有证据.
主要成果:
- 虽然研究已经对上腺发育和网膜区功能有了更深入的了解,但上腺炎的确切触发因素仍然难以捉摸.
- 包括11-ketotestosterone在内的11-oxy-androgen通路显示出作为上腺的标记物具有前途.
- 目前的定义显示PA的患病率很高 (女孩高达23%,男孩高达10%),但只有很少一部分可能会出现不良结果.
结论:
- 定义上腺和PA的新标准至关重要,以准确识别需要干预的儿童,并避免在正常变异中过度诊断.
- 进一步的研究是必不可少的,以阐明上腺癌背后的分子机制.
- 需要长期前性研究来将发育途径 (产前,产后生长,肥胖) 与上腺,青春期以及随后的健康结果联系起来.
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