体区对儿童和青少年肺功能的影响
Alina Ofenheimer1, Marie-Kathrin Breyer2, Emiel F M Wouters1
1Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.
Clinical nutrition (Edinburgh, Scotland)
|January 5, 2024
概括
肌肉质量对儿童和青少年的肺功能有积极的影响,而脂肪质量则有负面影响. 保持肌肉质量可能是终身肺部健康的关键.
科学领域:
- 儿科肺病学 儿科肺病学
- 身体组成分析 身体成分分析
- 增长和发展 增长和发展
背景情况:
- 身体构成显著影响肺功能,但肌肉和脂肪质量在成长过程中对静态肺体积的特定影响未得到充分研究.
- 以前的研究表明,身体组成和基于螺旋计的肺功能之间存在关联.
研究的目的:
- 调查尾肌肉质量 (骨肌肉质量) 和脂肪质量与儿童和青少年强制和静态肺功能测量之间的关联.
- 为了探索肺功能变化相对于肺生长期间身体组成的变化.
主要方法:
- 从LEAD研究中对1489名儿童和青少年 (6-18岁) 的截面和纵向分析.
- 双能量X射线吸收度 (DXA) 测定尾肌肉质量指数 (ALMI) 和脂肪质量指数 (FMI).
- 螺旋测量 (FEV1,FVC) 和身体囊造影 (TLC,RV,FRC) 用于测量肺功能.
主要成果:
- 尾肌瘦质量指数 (ALMI) 与1秒内强制呼气体积 (FEV1),强制生命能力 (FVC) 和肺总容量 (TLC) 有积极关联.
- 脂肪质量指数 (FMI) 与肺功能指标相反相关,包括功能剩余容量 (FRC) 和剩余体积 (RV).
- 在童年和青春期增加的肌肉质量增加与FVC和TLC的增加有关.
结论:
- 这项研究强调了肌肉质量与脂肪质量对静态和动态肺体积的明显影响.
- 在儿科和青少年发育期间促进和维持骨肌肉质量可能是成人肺部健康的关键预防策略.
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