在COVID-19感染后患有睡眠障碍的患者中,白质微观结构的改变
Haixia Qin1, Gaoxiong Duan2, Kaixuan Zhou2
1Medical College of Guangxi University, Guangxi University, Nanning, 530004, Guangxi, China; Department of Radiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, 530021, Guangxi, China.
Sleep medicine
|January 5, 2024
概括
患有睡眠障碍的COVID-19幸存者表现出白质 (WM) 变化和炎症,特别是在右下面的前后囊 (IFOF). 这些神经炎症标志物和WM异常在三个月后往往会改善.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 在COVID-19之后,睡眠障碍 (SD) 的潜在机制,即冠状失眠,尚未得到充分理解.
- 在COVID-19后调查白质 (WM) 完整性和炎症标志物对于理解持续性SD至关重要.
研究的目的:
- 为了检查WM微观结构和炎症因子变化在急性阶段的COVID-19患者SD.
- 在3个月的随访中评估这些变化的恢复情况.
主要方法:
- 扩散张力成像 (DTI) 和基于通道的空间统计 (TBSS) 用于分析WM微观结构.
- 测量了周围血液的炎症性细胞因子,包括互白素-1β (IL-1β).
- 评估了匹兹堡睡眠质量指数 (PSQI) 评分,并分析了与DTI和细胞因子数据的相关性.
主要成果:
- 两个COVID-19组 (有SD和没有SD) 都显示出广泛的WM异常.
- 患有SD的COVID-19患者在右下面的前后筋 (IFOF) 和左皮质脊髓管 (CST) 中表现出特定的WM变化,以及IL-1β水平升高.
- 这些WM异常和IL-1β水平与PSQI得分相关,并在3个月后表现出趋向于正常化,症状有所改善.
结论:
- 右侧IFOF和左侧CST的变化,以及IL-1β的升高,是与COVID-19诱导的SD相关的关键神经炎症标志物.
- 这些发现为COVID-19恢复的背景下睡眠障碍的神经炎症病原发生提供了新的见解.
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