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Updated: Jul 6, 2025

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MRPL21通过TP53突变诱导的亡性耐药性促进HCC的扩散

Tao Ma1, Ya-Bin Huang2, Jing Chen1

  • 1Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China; Research Center of Clinical Medicine, Nantong University, Affiliated Hospital of Nantong University, Nantong, China.

Tissue & cell
|January 5, 2024
PubMed
概括

线粒体核糖体蛋白L21 (MRPL21) 促进肝细胞癌 (HCC) 的生长和存活. 沉默MRPL21会诱导细胞亡和细胞循环停止,这表明MRPL21是HCC治疗的潜在治疗标.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.肝细胞癌 (HCC) 是一种肝细胞癌.在 MRPL21 课程中,努特林-3是一种反应性氧物种 (ROS) 是一种反应性氧物种.这种突变是TP53突变.

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