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Updated: Jul 6, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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均衡的EGFR和微管类双抑制剂的设计

Yifan Liu1, Qiuya Ma2, Xiangyu Kong1

  • 1Department of Medicinal Chemistry, Hebei Medical University, Shijiazhuang, China.

Bioorganic chemistry
|January 5, 2024
PubMed
概括

一种新型的双抑制剂,化合物10c,有效地向EGFR激酶和微管聚合. 这种有前途的抗癌剂在临床前模型中显示出显著的疗效,因此需要进一步研究瘤治疗.

关键词:
阿里尔形式氨基酸.双目标抑制剂的双目标抑制剂对于EGFR基因酶来说,这是一个很大的问题.基纳氨酸氨酸是什么图布林 (Tubulin) 是一种原蛋白.

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