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Updated: Jul 6, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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蛋白质组学:解码小细胞肺癌的新维度

Haobin Chen1, Benjamin J Drapkin2, John D Minna2

  • 1Division of Oncology, Department of Medicine, Washington University in Saint Louis, St Louis, MO, USA.

Cell
|January 5, 2024
PubMed
概括

研究人员绘制了小细胞肺癌 (SCLC) 瘤的蛋白质和蛋白质特征. 这种详细的生物学洞察力揭示了治疗这种具有挑战性的癌症的新弱点.

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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相关概念视频

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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