排泄性神经血管AMD是一种慢性疾病吗? 在抗VEGF治疗下对长期进展的分析
Marie-Louise Gunnemann1,2, Martin Ziegler3, Marius Book4
1Augenärzte, Detmold, Deutschland.
概括
神经血管与年龄相关的黄斑变性 (nAMD) 通常需要长期的抗VEGF治疗,大多数患者需要连续治疗多年. 这表明nAMD是一种慢性疾病,需要主动管理以维持视力健康.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗治疗 医疗治疗
背景情况:
- 排泄性新血管与年龄相关的黄斑变性 (nAMD) 用抗VEGF疗法治疗.
- 治疗策略历史上假设MNV痕和计划退出策略.
- 本研究检查了在现实世界nAMD病例中抗VEGF治疗的长期疗效和必要性.
研究的目的:
- 在抗VEGF疗法下调查长期痕转化在MNV的假设.
- 分析nAMD患者的现实生活,长期治疗模式和结果.
- 评估对nAMD管理所需的抗VEGF治疗的持续时间和强度.
主要方法:
- 从97名患有nAMD的患者中,对150只眼睛的队列进行了平均5.1年的跟踪 (范围为1-14年).
- 治疗采用了使用拉尼比祖马布,阿弗利伯塞普特或贝瓦西祖马布的预先建议 (PRN) 疗法.
- 治疗时间,强度和结果被评估到2022年.
主要成果:
- 大约80%的眼睛需要持续的长期抗VEGF治疗.
- 在12%的病例中,由于稳定,治疗可以中止.
- 眼睛的恶化导致8.7%的眼睛停止治疗;持续治疗通常涉及6-9注射/年,在2013年后增加.
结论:
- 大多数nAMD患者 (约. 80%) 长期,强烈需要抗VEGF治疗.
- 这支持将nAMD归类为需要主动管理的慢性疾病.
- 持续的治疗坚持对于最佳的长期视觉结果和预防不可逆转的视力损失至关重要.
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