相关实验视频

Updated: Jul 6, 2025

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

科多诺普西斯兰塞奥拉塔多糖改善高脂肪饮食诱导的产后缺血症通过刺激益生素受体介导的Jak2/Stat5信号传递

Shun Chen¹, Miao Long¹, Xue-Ying Li¹

¹School of Food and Biological Engineering, Hefei University of Technology, No 193 Tunxi Road, Hefei 230009, People's Republic of China.

International journal of biological macromolecules

|January 5, 2024

概括

在小鼠中,使用Codonopsis lanceolata多糖 (PCL) 逆转了高脂肪饮食引起的低胆症. 通过激活由益生菌受体介导的JAK2/STAT5信号通路,PCL改善了乳腺功能和新陈代谢.

科学领域:

药理学药理学是指药理学的学科.
营养营养营养营养营养
生殖生物学生殖生物学

背景情况:

高脂肪饮食 (HFD) 诱导代谢障碍,并可能对哺乳期产生负面影响.
缺血,或不足的牛奶产量是一个重大问题,可能与饮食引起的代谢功能障碍有关.
传统中医成分越来越多地被探索其健康益处.

研究的目的:

为了研究Codonopsis lanceolata多糖 (PCL) 对小鼠中HFD诱导的低的改善作用.
阐明PCL对乳腺功能和新陈代谢产生影响的潜在分子机制.

主要方法:

用PCL口服给小鼠,这些小鼠被养为HFD.
评估代谢参数,包括体重,肝硬化,脂肪细胞大小和葡萄糖/脂质代谢.
乳腺发育和细胞增殖的组织学分析.
流细胞计用于乳腺上皮细胞分析.
西方斑点和信号通路的分子分析 (JAK2/STAT5,PRL/PRLR).

主要成果:

服用PCL可以抵消HFD诱导的体重增加,肝硬化和脂肪细胞缩.
在HFD养的小鼠中,PCL改善了葡萄糖和脂质代谢.
PCL增强了乳腺发育,导管生长和乳腺生成,促进了上皮细胞的增殖和分化.
在PCL上调的前性蛋白 (PRL) 和前性蛋白受体 (PRLR) 水平,激活JAK2/STAT5信号通路.

结论:

科多诺普西斯兰塞奥拉塔多糖 (Codonopsis lanceolata polysaccharide,简称PCL) 有效地改善了小鼠的高脂肪饮食诱导的低心力症.
通过PRLR介导的JAK2/STAT5信号通路,PCL通过改善代谢健康和促进乳腺发育而起作用.
这些发现支持使用PCL作为潜在的治疗药物治疗低银,并强调其在中国传统医学的功能成分中的作用.

关键词:

科多诺普西斯兰塞奥拉塔是一种多糖体.这就是"Hypogalactia"的意义.哺乳腺腺体哺乳腺体

更多相关视频

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

相关概念视频

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

GPCRs Regulate Adenylyl Cylase Activity

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...