多功能聚合物guanidine和hydantoin胺,具有广泛的生物杀菌活性
Lev Bromberg1, Beatriz Magariños2, Beatriz S Torres2
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
International journal of pharmaceutics
|January 5, 2024
概括
新的抗病毒聚合物含有化比古安化和水素组,显示出对病毒,真菌和细菌的强化生物杀伤活性. 这些生物相容的N-胺聚合物为流行病准备提供了有前途的非漂水涂层.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 随着COVID-19的流行,人们越来越需要先进的抗病毒表面材料.
- 现有的生物制剂面临着过度使用和潜在耐药性的挑战.
- 具有增强抗微生物特性的新型聚合物对于未来的流行病准备至关重要.
研究的目的:
- 为了研究新型的多氨酸与比古安化,瓜尼丁和水胺组功能化,以增强生物杀伤活性.
- 开发具有强大的抗病毒,抗真菌和抗菌性能的素化N-胺聚合物.
- 评估这些聚合物的生物相容性和潜在应用,作为防洗涂料.
主要方法:
- 合成和化聚氨酸包括聚乙烯 (PVG),聚乙烯 (PAH),聚乙烯 (PAH) 和聚乙烯 (PHMB).
- 通过在位低酸 (HOBr或HOCl) 处理生成的N-胺.
- 评估了对HCoV-229E的杀菌活性,对C. albicans的杀菌活性,以及对MRSA和VRE的杀菌活性.
- 使用HeLa细胞单层评估细胞毒性.
主要成果:
- 化显著增强了所有测试的聚合物对HCoV-229E的杀毒活性.
- 化PHMB-Br在1 mg/L时表现出高效率 (> 5),在10 mg/mL时完全抑制.
- 化PVG-Br和PAH-Br表现出杀菌活性,而PHMB则是一种真菌.
- 所有测试的聚合物都显示出对抗性菌株 (MRSA,VRE) 的极佳杀菌活性.
- 化聚合物对HeLa细胞无毒,表明具有良好的生物相容性.
结论:
- 从聚氨酸中提取的化N-胺聚合物表现出强大且广泛的抗菌活性.
- 这些聚合物对病毒,真菌和细菌有效,包括耐药菌株.
- 开发的N-胺聚合物是生物相容的,适合制造不水抗菌涂层.
- 这些材料对抗疫情预防和控制的生物制剂武器库来说是一个有价值的补充.
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