慢性移植与宿主疾病相关的肌肉:免疫调节疗法的严重程度和反应
Supriya Rastogi1, Ellen J Kim1, Joel M Gelfand1
1Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Transplantation and cellular therapy
|January 5, 2024
概括
慢性移植对宿主疾病 (cGVHD) 的肌肉显著影响生活质量. 外体光 (ECP) 治疗减少了类固醇耐药cGVHD患者的频率.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 肌肉是慢性移植对宿主疾病 (cGVHD) 的常见和衰弱症状.
- 目前国家卫生研究院 (NIH) 的标准没有充分地将肌肉作为应对措施.
- 缺乏对免疫调节疗法的反应的描述和理解.
研究的目的:
- 描述类固醇耐药cGVHD患者进行体外光聚变 (ECP) 的肌肉的频率,持续时间和疼痛.
- 评估ECP对此患者群体肌肉症状的影响.
主要方法:
- 2021年4月至2023年4月期间,对22名接受ECP治疗类固醇耐药cGVHD的患者进行的单中心队列研究.
- 分析了9名患者 (41%),他们在ECP开始时患有肌肉.
- 收集了关于的频率,持续时间,疼痛和NIH全球严重性得分的数据,平均随访时间为28周.
主要成果:
- 89% (8/9) 的患者经历了肌肉频率的显著下降 (中位数为每周5次至每周<1次).
- 肌肉的持续时间和疼痛水平没有显示出有意义的变化.
- 在33% (3/9) 的患者中,NIH全球严重性得分有所改善,在67% (6/9) 的患者中保持稳定.
结论:
- 肌肉是cGVHD的重要并发症,可能会对像ECP这样的免疫调节疗法产生反应.
- 减少肌肉的频率表明ECP的潜在好处.
- 肌肉的频率需要进一步验证,作为cGVHD的临床反应指标.
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