Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Capsid-engineered AAV vector overcomes a key intracellular barrier and efficiently transduces spiral ganglion neurons in adult mice.

Molecular therapy. Advances·2026
Same author

Severe and profound hearing loss in patients with multiple sensory impairments: increased incidence of cognitive impairment.

Brazilian journal of otorhinolaryngology·2026
Same author

Extracellular vesicle-mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice.

Science translational medicine·2025
Same author

Gene therapy for inner ear disease: the next targets.

Current opinion in otolaryngology & head and neck surgery·2025
Same author

Testing for genetic and viral etiologies in congenital hearing loss based on a survey of cochlear implant centers: proposed HEARRING group consensus and future directions.

Acta oto-laryngologica·2024
Same author

HEARRING group genetic marker study: genetic background of CI patients.

Acta oto-laryngologica·2024

相关实验视频

Updated: Jul 6, 2025

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

13.3K

细胞外囊泡用于开发有针对性的听力损失治疗.

Xiaoshu Pan1, Yanjun Li2, Peixin Huang3

  • 1Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.

Journal of controlled release : official journal of the Controlled Release Society
|January 5, 2024
PubMed
概括

细胞外囊泡 (EVs) 在治疗听力损失方面表现有前途. 生物工程和人工智能增强了这些天然纳米颗粒的内耳传递,用于治疗应用.

关键词:
外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.听力损失 听力损失内耳组织的内耳组织.有针对性的交付目标.

更多相关视频

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

10.9K
Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
07:32

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

16.3K

相关实验视频

Last Updated: Jul 6, 2025

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

13.3K
Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

10.9K
Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
07:32

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

16.3K

科学领域:

  • 生物医学工程 生物医学工程
  • 再生医学是一种再生医学.
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科

背景情况:

  • 听力损失是一个重大的健康问题,通常用局部药物输送来治疗.
  • 细胞外囊泡 (EVs) 正在成为治疗听力障碍的有希望的天然治疗剂.
  • 目前的治疗方法在向的治疗和有效性方面面临挑战.

研究的目的:

  • 审查细胞外囊泡 (EVs) 对听力损失的治疗潜力.
  • 探索生物工程和人工智能的进步,以实现基于电动汽车的内耳传输.
  • 讨论功能化的EV用于听力再生的临床转化.

主要方法:

  • 对EV用于听力损失的临床前和临床研究进行系统审查.
  • 对EV功能化和定位的生物工程策略的分析.
  • 对优化EV准连接体的AI算法进行讨论.

主要成果:

  • 在临床前和临床研究中,EV在减轻听力损伤方面显示出显著的潜力.
  • 生物工程技术使电动汽车能够作为有效的生物衍生治疗材料.
  • 人工智能驱动的方法正在推进用于内耳传递的准配体的识别.

结论:

  • 功能化的电动汽车代表了一个有希望的下一代治疗听力损失的疗法.
  • 针对性地将EV送入内耳对于成功的治疗结果至关重要.
  • 需要进一步的研究和临床转化,才能充分发挥基于EV的疗法的潜力.