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细胞外囊泡用于开发有针对性的听力损失治疗

Xiaoshu Pan¹, Yanjun Li², Peixin Huang³

¹Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.

Journal of controlled release : official journal of the Controlled Release Society

|January 5, 2024

概括

细胞外囊泡 (EVs) 在治疗听力损失方面表现有前途. 生物工程和人工智能增强了这些天然纳米颗粒的内耳传递,用于治疗应用.

科学领域:

生物医学工程生物医学工程
再生医学是一种再生医学.
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

听力损失是一个重大的健康问题,通常用局部药物输送来治疗.
细胞外囊泡 (EVs) 正在成为治疗听力障碍的有希望的天然治疗剂.
目前的治疗方法在向的治疗和有效性方面面临挑战.

研究的目的:

审查细胞外囊泡 (EVs) 对听力损失的治疗潜力.
探索生物工程和人工智能的进步,以实现基于电动汽车的内耳传输.
讨论功能化的EV用于听力再生的临床转化.

主要方法:

对EV用于听力损失的临床前和临床研究进行系统审查.
对EV功能化和定位的生物工程策略的分析.
对优化EV准连接体的AI算法进行讨论.

主要成果:

在临床前和临床研究中,EV在减轻听力损伤方面显示出显著的潜力.
生物工程技术使电动汽车能够作为有效的生物衍生治疗材料.
人工智能驱动的方法正在推进用于内耳传递的准配体的识别.

结论:

功能化的电动汽车代表了一个有希望的下一代治疗听力损失的疗法.
针对性地将EV送入内耳对于成功的治疗结果至关重要.
需要进一步的研究和临床转化,才能充分发挥基于EV的疗法的潜力.

关键词:

外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.听力损失听力损失内耳组织的内耳组织.有针对性的交付目标.

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