霍尔梅西斯决定了寿命
Edward J Calabrese1, Marc Nascarella2, Peter Pressman3
1School of Public Health and Health Sciences; University of Massachusetts, Morrill I - Room N344, Amherst, MA 01003, USA.
Ageing research reviews
|January 5, 2024
概括
寿命可以通过各种干预措施延长,包括补充剂和禁食,在hormesis的原则之内. 这种生物反应始终显示不同物种的适度寿命增加.
科学领域:
- 老年学和长寿研究研究.
- 细胞和分子生物学 细胞和分子生物学
- 药理学和毒理学 药理学和毒理学
背景情况:
- 衰老是一个复杂的过程,受遗传和环境因素的影响.
- 许多干预措施,包括饮食,药物和生活方式的改变,正在探索延长寿命.
- 荷尔梅斯是一个双相剂量反应,为理解生物可塑性和适应提供了一个框架.
研究的目的:
- 在hormesis框架内评估各种延长寿命的干预措施的有效性.
- 在不同模型和代理中确定寿命延长的共同定量特征.
- 探索霍梅西斯对人类衰老和公共健康的影响.
主要方法:
- 对延长寿命的药物和活动的研究进行系统审查和元分析.
- 分析来自各种模型生物 (酵母,线虫,昆虫,鱼,动物) 的数据.
- 霍梅西斯原理的应用,以量化描述寿命延长反应.
主要成果:
- 多种干预措施 (食补充剂,药物,热量限制,禁食,运动) 一致地证明了寿命延长.
- 寿命延长跟随了hormesis的定量特征,平均增长最多为30-60%.
- 这些抑制效应在各种生物模型,药物和测量终点中观察到.
结论:
- 霍尔梅西斯提供了一个统一的原则,用于理解由各种代理和活动诱导的寿命延长.
- 寿命延长的大小通常是适度的 (基于百分比),而不是指数的.
- 这些发现对衰老研究,疾病预防和社会规划有重大影响.
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