大型球形3D共价有机框架的尺寸可控合成,作为高效的线上固相提取吸附剂,与HPLC相结合
Ying Chen1, Qiong He1, Yuyang Liu1
1College of Chemistry and Chemical Engineering, Hubei Key Laboratory of Biomass and Eco-dyeing and Finishing, Wuhan Textile University, Wuhan, 430073, China.
Analytica chimica acta
|January 5, 2024
概括
研究人员开发了大型球形共价有机框架 (COF) 用于在线固体相提取 (SPE) 与HPLC相结合. 这项创新使COF的直接使用成为可能,克服了以前的局限性,并提高了环境样本的分析灵敏度.
科学领域:
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
- 分离科学 分离科学
背景情况:
- 共价有机框架 (COF) 为分离应用提供高表面积和吸附能力.
- 现有的COF的小尺寸和不规则的形状导致高柱反压和在线SPE与HPLC相结合的低效率.
- 合成大尺寸球形COF (>3μm) 是具有挑战性的,但对于克服这些局限性至关重要.
研究的目的:
- 开发一种适合在线SPE的合成大尺寸球形COF的方法.
- 评估这些新型COF作为HPLC合SPE的包装材料的性能.
- 建立一种敏感的分析方法,用于检测水样中的微量污染物.
主要方法:
- 采用两步策略,在10-90μm范围内以可控制的尺寸合成大尺寸球形3DCOF (COF-320和COF-300).
- 合成的COF因其表面积,结晶性,化学/机械稳定性和可重复性而具有特征.
- 使用COF作为线上SPE吸附剂与HPLC相结合,用于分析双F.
主要成果:
- 两种类型的大型球形COF,COF-320和COF-300,已成功合成,具有良好的性能.
- 对于双F,COF-320表现出高结合能力 (Qmax为452.49 mg/g),低柱子逆压 (6-8 psi),以及出色的重复使用性 (>30个循环).
- 开发的线上SPE-HPLC-UV方法实现了高灵敏度,富化系数为667,LOD为0.3 ng/mL,并在真实水样中获得了精确的回收.
结论:
- 本研究介绍了首次成功合成大尺寸球形COF (10-90μm) 用于在线SPE与HPLC相结合的直接使用.
- 开发的COF有效地解决了先前材料的局限性,使有效的分离和分析成为可能.
- 分析方法显示,在环境水样中快速和灵敏地检测微量双F的分析方法具有很大的潜力.
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