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Updated: Jul 18, 2026

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

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利用基于分子间G-四重复的空间封闭效应来加速CRISPR/Cas12a的激活,使PML/RARA融合基因的超敏感检测成为可能

Xinrui Wang1, Dan Zheng2, Chengyi Wang3

  • 1Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350000, PR China; NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-Human Primate (Fujian Maternity and Child Health Hospital), Fuzhou, Fujian, 350000, PR China.

Analytica chimica acta
|January 5, 2024
PubMed
概括

这项研究引入了一种新的CRISPR/Cas12a和滚动圆放大平台,用于检测急性前列细胞白血病 (APL) 中的PML-RARA异型. 该系统提供了一种快速可靠的APL诊断和预后方法.

关键词:
这就是CRISPR/Cas12a.分子间G-四重复合体在PML/RARA融合基因的过程中,在RCA RCA中使用.空间限制效应的空间限制效应.

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