闭环光遗传乱的眼运动小脑:证据一个内部的萨卡德模型
Robijanto Soetedjo1,2, Gregory D Horwitz3,2
1Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195 robi@uw.edu.
概括
小脑中的眼运动虫 (OMV) 在眼运动中扮演着双重角色. 它作为ipsiversivesaccades的前向模型和反向saccades的反向模型,确保精确的凝视控制.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 发动机控制器的控制器
背景情况:
- 精确的眼运动依赖于运动控制的内部模型.
- 小脑,特别是眼运动虫 (OMV),被假设为编码这些内部模型.
- OMV可以参与预测 (前进) 和校正 (反向) 反循环,以获得saccade准确性.
研究的目的:
- 调查 OMV 在前向和反向建模中的特定作用.
- 确定OMV如何为ipsiversive和逆向saccades的准确性做出贡献.
主要方法:
- 使用通道罗多普辛-2的猿OMV中Purkinje细胞的光遗传刺激.
- 萨卡德触发的光脉冲是在ipsiversive和逆向萨卡德的不同阶段传递的.
- 分析动力学,包括速度,减速和最后的视线位置.
主要成果:
- 在ipsiversive saccades期间的刺激减缓了减速,这表明在预测建模中发挥了作用.
- 在逆向冲动期间的刺激降低了初始速度,但随后出现了补偿性再加速,表明参与力生成.
- 这些效应依赖于延迟,并根据刺激持续时间进行缩放,与神经集成相一致.
结论:
- OMV对冲击控制的贡献取决于方向.
- 两侧的OMV作为前向模型的一部分,预测眼睛的移位.
- 反侧的OMV参与了一个反向模型,生成用于精确眼睛运动的运动指令.
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