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类型I光动力学疗法通过Pt-协调诱导类型II光敏化剂进入超分子复合体

Xiaoxue Fan¹, Shibo Lv^1,2, Fangyuan Lv^1,2

¹Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, Shandong, 266237, China.

Chemistry (Weinheim an der Bergstrasse, Germany)

|January 5, 2024

概括

这项研究引入了一种新的超分子复合物,可以增强反应性氧物种 (ROS) 的生成,以改善光动力学疗法 (PDT). 该综合体在体外表现出卓越的ROS生产和光化疗性能.

科学领域:

材料科学材料科学材料科学
化学化学化学
生物医学工程生物医学工程

背景情况:

(Pt) (II) 复合物正在研究光动力疗法 (PDT),因为它们作为化疗剂和PDT增强剂的双重作用.
在开发基于Pt的PDT药物的关键挑战是,与其前体光敏化剂配体相比,在最终复合体中增强反应性氧物种 (ROS) 的产生.

研究的目的:

设计和合成一种基于协调的新型二维光敏化复合物, (Cz-BTZ-Py) 2Pt(OTf) 2.
研究新综合体中ROS生成的机制,并将其效率与前体光敏化剂配体进行比较.
为了评估开发的复杂的体外光化疗性能.

主要方法:

二维光敏化复合物的合成 (Cz-BTZ-Py) 2Pt(OTf) 2.
谱分析以确定吸收波长变化和刺激合效应.
测量ROS发电效率,特别是I型ROS (O2•−).
在体外评估使用纳米粒子的复杂光化疗的疗效.

主要成果:

合成的复合物 (Cz-BTZ-Py) 2Pt(OTf) 2与Cz-BTZ-Py连接体相比,其吸收波长呈红移.
该综合体显示了增强的ROS产生效率,主要是通过I型ROS (O2•−) 生产.
这种增强的ROS生成归因于光敏剂配体之间的激子合引起的减少的能量差距 (ΔE_ST).
在体外研究表明, (Cz-BTZ-Py) 2Pt(OTf) 2纳米颗粒的光化疗性能非常出色.

结论:

开发的超分子复合物有效地增强了ROS生成,用于增强光动力学治疗.
该机制涉及刺激子合,导致I型ROS产量增加.
这项研究提供了一个有前途的策略,用于设计新型I型光敏剂,以实现高效的PDT应用.

关键词:

癌症治疗治疗癌症治疗化疗化疗是一种化学疗法.光动力学疗法光动力学疗法光敏化剂是一种光敏化剂.的高分子复合体.

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