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根据驱动线定位的驱动线感染在左心室辅助器件植入体接受者的左心室辅助器件接受者
Volker Lauenroth1, Armin Zittermann1, Stefan Lucke1
1Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr University Bochum, Bad Oeynhausen, North Rhine-Westphalia, Germany.
The International journal of artificial organs
|January 5, 2024
概括
身体内循环定位在左心室辅助器件 (LVAD) 患者中在一年内没有显著减少驱动线感染 (DLI). 需要进一步的研究来证实这些关于DLI预防策略的发现.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 手术技术 手术技术
背景情况:
- 驱动线感染 (DLI) 是左心室辅助器件 (LVADs) 患者的重大并发症.
- 对DLI的预防策略对于改善患者的治疗结果和设备寿命至关重要.
- 身体内循环定位是探索减轻感染风险的策略之一.
研究的目的:
- 评估体内循环定位在预防LVAD患者的驱动线感染 (DLI) 的有效性.
- 为了在一年的随访期内比较具有和没有体内循环定位的患者之间的DLI率.
主要方法:
- 一个前性的,开放的,二对二因子临床试验,涉及80名LVAD患者.
- 患者被随机分为两组:体内循环定位 (n=40) 和没有体内循环定位 (n=40).
- 使用驱动器专家STagINg和carE (DESTINE) 系统 (第二阶段或更高) 定义了DLI;随访时间为一年.
主要成果:
- 总共有29名患者 (36%) 在一年内发生了DLI.
- 16个DLI发生在体内循环组中,13个发生在无循环组中.
- 卡普兰-梅尔分析显示,两组之间无DLI的统计学上显著差异 (p=0.33). 一年免受DLI的影响是51%的循环定位和62%的无循环定位.
结论:
- 这项临床试验没有证明体内循环定位在一年内在LVAD患者中降低DLI率方面具有统计学意义的好处.
- 该研究表明,与标准护理相比,体内循环定位可能不是预防DLI的优越策略.
- 需要进行更大规模的临床试验,以最终证实这些发现,并探索其他DLI预防方法.
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