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Updated: Jul 6, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

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通过对Myc的上调调节,WWOX促进了骨髓瘤的发展

Rania Akkawi1, Osama Hidmi1, Ameen Haj-Yahia1

  • 1The Concern Foundation Laboratories, The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research, IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Cell death & disease
|January 5, 2024
PubMed
概括

含有WW域的氧化还原酶 (WWOX) 损失通过上调骨髓干细胞中的Myc来加速骨髓瘤. 抑制Myc标MCM7减少瘤生长,揭示了这种侵袭性骨癌的治疗标.

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