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Updated: Jul 6, 2025

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay

Published on: September 10, 2016

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一个关于Frizzled-G蛋白合的框架,以及对PCP信号通路的影响

Zhibin Zhang1,2, Xi Lin1, Ling Wei3

  • 1iHuman Institute, ShanghaiTech University, Shanghai, China.

Cell discovery
|January 5, 2024
PubMed
概括

研究人员阐明了Frizzled受体 (FZD) 的激活机制,这些受体对Wnt信号传递和发育至关重要. 结构和功能研究揭示了一个共享的激活框架和癌症和白内障等疾病的潜在治疗点.

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