与抗精神病治疗相关的自主性不良反应的性别差异和相关的激素概况
Ingrid T Johansen1, Nils Eiel Steen2, Linn Rødevand2
1NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway. i.t.johansen@medisin.uio.no.
Schizophrenia (Heidelberg, Germany)
|January 5, 2024
概括
抗精神病药物 (AP) 可以引起自主性副作用,观察到显著的性别差异. 与APs相关的荷尔蒙变化可能解释这些性别特异性风险,特别是在心和心动减速方面.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 抗精神病药物 (AP) 的自主不良影响带来临床挑战.
- 关于性别差异和这些影响的潜在生物学途径的研究有限.
- 荷尔蒙调节可能在性别特定的AP副作用中起作用.
研究的目的:
- 为了研究常见的APs (奥兰扎宾,奎平,RISPERIDONE,ARIPIPRAZOLE) 的自主性不良影响的性别差异.
- 探索AP相关激素在这些性别特异性影响中的作用.
主要方法:
- 在1318名患有严重精神障碍的患者中,使用 Udvalg for Kliniske Undersøgelser (UKU) 的副作用量表分析了自主症状.
- 经年龄,诊断和多药学调整后勤回归.
- 自主症状和与AP相关的激素之间的关联分析.
主要成果:
- 特定的AP与明显的自主效应有关 (例如,阿里皮普拉/奎平的唾液变化,奥兰扎的恶心/心跳).
- 女人表现出更高的恶心,腹,便秘,多尿症/多腹,心/心风险.
- 观察到一个显著的性别xAP对心/心动的相互作用,在接受Risperidone治疗的男性中风险更高,与前素,皮质醇和胰岛素水平有关.
结论:
- 自主性不良影响与AP使用有关,具有显著的性别特异性差异.
- 激素特征,包括益乳素,皮质醇和胰岛素,都与性特异性自主性副作用有关.
- 研究结果强调了在与AP相关的自主功能障碍中考虑性别和荷尔蒙因素的重要性.
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