饮食乳化剂的消费加速了NOD小鼠1型糖尿病的发展
Clara Delaroque1, Benoit Chassaing2
1INSERM U1016, team "Mucosal microbiota in chronic inflammatory diseases", CNRS UMR 8104, Université Paris Cité, Paris, France.
NPJ biofilms and microbiomes
|January 5, 2024
概括
含有CMC和P80等乳化剂的工业化饮食在小鼠中加速1型糖尿病 (T1D) 的发展. 这些乳化剂破坏肠道微生物群,导致炎症并增加疾病风险.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
- 营养科学 营养科学
背景情况:
- 1型糖尿病 (T1D) 的患病率正在上升,这表明环境因素起着关键作用.
- 工业化饮食及其对肠道微生物群的影响与T1D的发展有关.
- 食乳化剂破坏肠道微生物群,可能导致炎症和代谢功能障碍.
研究的目的:
- 研究两种常见的食乳化剂 - - 碳氧甲基纤维素 (CMC) 和聚酸盐-80 (P80) - - 对T1D发展的影响.
- 评估乳化剂对肠道微生物群组成和功能以及T1D小鼠模型中的肠道炎症的影响.
主要方法:
- NOD小鼠是自发T1D的模型,长期暴露于CMC和P80.
- 监测了T1D发病率的变化,胰岛素自身抗体水平,肠道微生物群的组成/功能以及肠道炎症.
- 机器学习被用来分析微生物群破坏和疾病发展之间的关系.
主要成果:
- 长期暴露于CMC和P80加速了NOD小鼠的T1D发展.
- 乳化剂治疗增加了胰岛素自身抗体水平,并诱导了轻度肠道炎症.
- 观察到肠道微生物群组成和功能的显著改变,干扰的严重程度部分预测了疾病发病.
结论:
- 像CMC和P80这样的食乳化剂可以通过破坏肠道微生物群的稳定性和促进肠道炎症来加速T1D的发展.
- 这些发现表明,工业化饮食中的乳化剂可能会导致T1D发病率的增加.
- 主体遗传学,饮食和肠道微生物群之间的复杂相互作用在T1D病变发生过程中至关重要.
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